Comparison between 57Co-bleomycin, 99mTc-bleomycin and 111In-bleomycin as the Tumor Scanning Agents

Preparation of [111In]-Bleomycin radiopharmaceutical [Persian]

In this study, the preparation of 111In-Bleomycin complex was optimized for temperature, time, concentration and pH during several experiments. The results showed that by the addition of bleomycin to 111In-InCl3 sample (dried under flow of N2) and heating the mixture up to 90-100°C the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 Ci/mmol. The final s...

A comparison of cobalt (57Co) bleomycin scanning and contrast-enhanced CT scanning for assessment of the mediastinum in lung cancer.

Sixty patients with histologically proven lung cancer who had been accepted for mediastinoscopy or thoracotomy were prospectively entered into a study to evaluate computed tomographic (CT) scanning, 57Co-bleomycin scanning, and barium swallow in preoperative assessment of mediastinal lymph node metastasis. Fifty-six patients had thoracotomy at which all accessible lymph nodes were sampled. Twen...

Intracellular distribution of (14C)bleomycin and the cytokinetic effects of bleomycin in the mouse tumor.

The differential effects (BLM) on cycling and noncycling cells were investigated with a mouse ascites tumor in vivo. An i.p. injection of 37.0 or 111.1 mug BLM per g caused a decrease in tumor cell number but an increase in percentage of tumor cells in mitosis. There are no significant differences between the percentage labeled mitoses at various times after pulse labeling by tritiated thymidin...

preparation of [111in]-bleomycin radiopharmaceutical [persian]

in this study, the preparation of 111in-bleomycin complex was optimized for temperature, time, concentration and ph during several experiments. the results showed that by the addition of bleomycin to 111in-incl3 sample (dried under flow of n2) and heating the mixture up to 90-100°c the radiopharmaceutical can be obtained in 99.5% yield and a specific activity of 1.745 ci/mmol. the final sample ...

Chemistry of bleomycin. XIX Revised structures of bleomycin and phleomycin.